Covid-19 vaccine thread

[Bartholomew Gallacher]

Biden finds the right words:

 

[Sid]

The downside is that in the US the mask wearing has become such an issue, that tons of them seem to forget that simple six feet distancing, washing your hands and stay at home with even the slightest symptoms are far more effective and important in stopping the virus to spread.

 

[Innula Zenovka]

'Verify before you amplify': the BAME activists fighting Covid myths

Campaigners push back at influencers stoking fears over safety and lawfulness of vaccine

www.theguardian.com

 

[Essence Lumin]

Coffey County, Kansas, Nurses Refuse to Give COVID-19 Vaccines

Kansas is in the middle of a coronavirus emergency, but some health-care workers are spreading misinformation instead of healing.

www.thedailybeast.com

Evernote link because paywall

It's odd that story is popping up all over now. It's a six day old story.

Coffey County Health Department nurses decline to give the COVID vaccine

The Coffee County Health Department is preparing to help distribute the COVID-19 vaccine; however, none of their 4 nurses will be actually be administering it.

www.wibw.com

 

[Bartholomew Gallacher]

We've got a new mutation of SARS-CoV2, this time the changed part is the crucial spike protein. This renders antibodies generated by vaccination completely useless. In case you already had the disease it means you can be infected by this new strain of the virus.

Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore 501Y.V2 shows substantial or complete escape from neutralizing antibodies in COVID-19 convalescent plasma.

Question is now if other scientists are going to confirm this study and its results, or not.

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

SARS-CoV-2 501Y.V2, a novel lineage of the coronavirus causing COVID-19, contains multiple mutations within two immunodominant domains of the spike protein. Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore...

www.biorxiv.org

 

[Beebo Brink]

Looks like I'm going to spend the rest of my life cooped up in my house.

 

[Lucifer]

I got my first Jag on Monday. Left arm hurt like a bitch for just over a day, felt heavy and was as weak as fuck.

Fine now, and I can tell random women that my sperm is fuff of COVID antibodies.

 

[Arkady Arkright]

The fetid stench of corruption in our UK administration gets ever fouler - Tory donor Lord Ashcroft’s outsourcing firm lands £350m vaccination contract

 

[Sid]

We've got a new mutation of SARS-CoV2, this time the changed part is the crucial spike protein. This renders antibodies generated by vaccination completely useless. In case you already had the disease it means you can be infected by this new strain of the virus.

Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore 501Y.V2 shows substantial or complete escape from neutralizing antibodies in COVID-19 convalescent plasma.

Question is now if other scientists are going to confirm this study and its results, or not.

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

SARS-CoV-2 501Y.V2, a novel lineage of the coronavirus causing COVID-19, contains multiple mutations within two immunodominant domains of the spike protein. Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore...

www.biorxiv.org

The Pfizer medical director was on a Dutch talk show tonight and he explained that the vaccine attacks the whole spike protein, not only a part of it. So there is a good chance their vaccine will work on the mutations as well, at least partly.
He also told that it is possible for Pfizer to reprogram the vaccine within 6 weeks if needed.
But it would take a lot longer to get it approved again.

 

[Innula Zenovka]

We've got a new mutation of SARS-CoV2, this time the changed part is the crucial spike protein. This renders antibodies generated by vaccination completely useless. In case you already had the disease it means you can be infected by this new strain of the virus.

Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore 501Y.V2 shows substantial or complete escape from neutralizing antibodies in COVID-19 convalescent plasma.

Question is now if other scientists are going to confirm this study and its results, or not.

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

SARS-CoV-2 501Y.V2, a novel lineage of the coronavirus causing COVID-19, contains multiple mutations within two immunodominant domains of the spike protein. Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore...

www.biorxiv.org

Do we know anymore about it, like how infectious it is, and how likely you are to be develop symptoms and how serious they're likely to be?

 

[Aribeth Zelin]

We can't get the vaccine yet here at our pharmacy, but only because we're not health care workers or over 65. But the fact they have it in the pharmacies is good enough for me, and in a few weeks, I'll ask again so we can get it when its available.

A bit annoying though because friends of mine up in Smyrna are getting it, and one is only a couple years older than i am, and his wife is only a little younger [and I'm not -that- close to 65 yet.]

So, locally, even being a diabetic isn't enough to move me up the list, but I'm thinking by march we can get it.

 

[danielravennest]

He also told that it is possible for Pfizer to reprogram the vaccine within 6 weeks if needed.
But it would take a lot longer to get it approved again.

Apparently we are living in a future where drugs get software updates.

 

[Khamon]

Apparently we are living in a future where drugs get software updates.

you know, because the vaccine contains a chip, and stuff, you know, the mark

 

[Bartholomew Gallacher]

The Pfizer medical director was on a Dutch talk show tonight and he explained that the vaccine attacks the whole spike protein, not only a part of it. So there is a good chance their vaccine will work on the mutations as well, at least partly.
He also told that it is possible for Pfizer to reprogram the vaccine within 6 weeks if needed.
But it would take a lot longer to get it approved again.

Well according to this study he is wrong. They used blood plasma, which contained antibodies created as response to the other strains, and those didn't do anything to the virus at all.

I mean it makes sense. My limited understanding is this: proteins are really complicated, three dimensional structures. In order for an antibody to react with it it needs to fit it like a glove. If the protein changes, then it is like trying to fit a square into a circle, only on a much higher complicated level - impossible to do. No match.

Again question is still if the results of this study will be confirmed by others or not.

 

[Free]

you know, because the vaccine contains a chip, and stuff, you know, the mark

 

[Beebo Brink]

Rogue antibodies could be driving severe COVID-19

Evidence is growing that self-attacking ‘autoantibodies’ could be the key to understanding some of the worst cases of SARS-CoV-2 infection.

www.nature.com

 

[Innula Zenovka]

Well according to this study he is wrong. They used blood plasma, which contained antibodies created as response to the other strains, and those didn't do anything to the virus at all.

I mean it makes sense. My limited understanding is this: proteins are really complicated, three dimensional structures. In order for an antibody to react with it it needs to fit it like a glove. If the protein changes, then it is like trying to fit a square into a circle, only on a much higher complicated level - impossible to do. No match.

Again question is still if the results of this study will be confirmed by others or not.

As I understand it, though, both the Pfizer and Oxford/AstraZeneca work vaccines by targeting the characteristic protein spikes on the outside of the virus , which are harmless in themselves, but which the virus uses to hook onto and attack the body's cells.

The vaccination starts producing the spikes (and only the spikes) inside the patient's body, and the body's immune system learns to recognise and destroy them.

So if in future the body's immune system recognises those spikes, it knows to attack them and anything of which they're part -- that is, the antibody is reacting to the spike, not to the more complex geometrical object of which the spike is only a component part.

So if the new strain's spikes are sufficiently similar to those of older variants, there's a good chance the Pfizer and Oxford vaccines will be effective against the new strain too, however it may differ from earlier strains in other ways.

That's my understanding, anyway.

 

[Aribeth Zelin]

As I understand it, though, both the Pfizer and Oxford/AstraZeneca work vaccines by targeting the characteristic protein spikes on the outside of the virus , which are harmless in themselves, but which the virus uses to hook onto and attack the body's cells.

The vaccination starts producing the spikes (and only the spikes) inside the patient's body, and the body's immune system learns to recognise and destroy them.

So if in future the body's immune system recognises those spikes, it knows to attack them and anything of which they're part -- that is, the antibody is reacting to the spike, not to the more complex geometrical object of which the spike is only a component part.

So if the new strain's spikes are sufficiently similar to those of older variants, there's a good chance the Pfizer and Oxford vaccines will be effective against the new strain too, however it may differ from earlier strains in other ways.

That's my understanding, anyway.

Same; and I'm just going to trust that the companies making the vaccine understand their vaccines better than I do as just a curious layperson.

 

[Jolene Benoir]

Report: Biden Admin Discovers Trump Had Zero Plans For COVID Vaccine Distribution

As they were settling into the White House on Wednesday, Biden administration officials were reportedly stunned to discover that President...

talkingpointsmemo.com

No great surprise, here.

 

[Free]