Since I live in Georgia, and already knew where to look up the state COVID statistics, I compared deaths in the Atlanta metro counties vs the rest of the state. As of now, 0.1% of the Atlanta folks have died from COVID, while 0.3% of the rest of the state has. That division also is pretty close to how the state divides in elections. Atlanta also has a higher vaccination rate than the rest of the state. So the Delta variant will be hitting the rest harder.
If we project this behavior across the country, this means the R's will be "owning the libs" by dying more. This makes it less likely they can win close races, in addition to all the other reasons (demographic shifts, unlikable policies, etc.). They will still win the hardcore conservative areas, but lose more of the competitive seats.