If the Middle East wouldn't matter to the states they wouldn't have had meddled so much with the interior affairs of Persia since decades.
A stable Middle East is a major national security concern of the states, because of oil and petrochemical products. The funny thing is that the states could have become almost independent from it with its fracking boom going on, but thanks to capitalism never bothered to. Because they would either need new refineries, or adapt old one to the fracking oil. Investments of billions, they never bothered to do, because purchasing it from the Middle East is cheaper and selling the own surplus to the world, which could have powered the states, also easier to do.
The states are still dependent on oil from the Middle East by own choice and laziness.
Also another thing: all countries on the Arabian peninsula have no farming sector big enough to sustain themselves due to being in a hot desert. So they are thankfully buying tons of wheat, corn, meat and other stuff from everywhere, including America.
The biggest threat to national security of countries on the peninsula is having no electrical power: air conditioning will cease to work, which in summers with about up to 50 degress Celsius/122 degrees Fahrenheit is unfun. Cooling of food will also stop working, also desalination plants and gas stations. It would be a big chaos within a few days.