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To be clear, by "life support systems" we're not just talking about like, the oxygen. We're talking about stuff like climate control, food and water, waste handling, and rest and recreation.I don't think there's any difference in the behavior of the life support system in low Earth orbit and in Lunar flyby.
Arguably, the oxygen and climate controls would work exactly the same just orbiting Earth. A big part of how all that other stuff works though depends on exactly how the humans interact with it, and I'll bet people's behavior and habits and rhythms can be different enough between like a translunar flight and just hanging out in Earth orbit to have an effect on how those systems perform over time. The light/dark cycle will be different and we already know that has an impact on things like sleep cycles; and there also HAS to be at least some psychological effect watching the world get smaller in the window and the Moon get bigger. Not to mention *passing* the Moon and still going for a while. I think there's enough of a possibility for it to change things like consumption and living habits that it deserves an actual live trial and not just a simulated guess.










