Coronavirus Updates

Dakota Tebaldi

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In Louisiana it's 12,500 cases now and 410 dead.
That was two days ago; as of today it's 14,800 cases and 512 dead.

That puts us with the fourth-highest case-count in the US, behind Michigan, New Jersey, and New York; pulling ahead of California, Massachusetts and Pennsylvania. This is pretty uncool being that Louisiana is only the 25th-largest state by population, and all those states have more people than us (almost all of them several times more people). The epicenter by far remains New Orleans, with the Shreveport and Monroe metro areas hosting smaller hotspots. My city is doing surprisingly well with only 100 cases and 4 deaths, but we have a population roughly equivalent to Monroe which has over twice as many cases (but only 1 recorded fatality).
 

Sovereignty

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Dr. Harris may be concerned about the potential effects of patients with undiagnosed heart conditions that can be fatal as a side effect.
Which attending physicians would take into account when evaluating risks. Also, in ICU they would be able to detect an abnormal EKG, I would expect.
ETA: EKG's are easy to do even outside ICU. They do prescribe the drug to lupus and rheumatoid arthritis patients after all. Her dire warnings don't hold water.
ETA2: Anyone can disagree with me, but I know hospitals in New York are permitted to prescribe hydroxychloroquine for COVID, and I expect the same is true elsewhere. The thing I like about Cuomo is that he's not pulled into the soap operas. If Harris had talked about shortages, that would be different. Instead she went for scare tactics and presented an unrealistic picture of how medicine works, as if off-label use did not exist.
 
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Veritable Quandry

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According to the little reading I have done, the drugs will cause disrythmia in patients with no indication of heart disease. Start passing it out like candy in the middle of a medical crisis and it is risky as fuck. The question is is the percentage it may save higher then the percentage it may kill? That's the point of a controlled study.
 

Sovereignty

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According to the little reading I have done, the drugs will cause disrythmia in patients with no indication of heart disease. Start passing it out like candy in the middle of a medical crisis and it is risky as fuck. The question is is the percentage it may save higher then the percentage it may kill? That's the point of a controlled study.
Cuomo was asked about the controlled study underway in New York state. He pointed out in his reply that hospitals are free to use the drug at their discretion.
ETA: I should point out that there is not enough of the drug available to "start passing it out like candy", so that's quite impossible.
 
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Innula Zenovka

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There are no general elections needed in that case.
There will be an election procedure in his party (the Conservatives) though.
But let's hope he will recover.
If he's incapacitated for any length of time, or worse, HM will have be invited to ask someone to act as her Prime Minister.

The Cabinet Secretary is doubtless at this moment checking the files and taking legal advice but I'd have thought that, one way or another, the cabinet -- possibly in consultation with the leaders of the opposition parties -- would agree on a caretaker PM for the duration of the crisis, and then step down when Johnson is able to return to his duties, or to run in a proper election under the Conservative Party's normal procedures should Johnson not be able to take up his position again.
 
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Kara Spengler

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/me throws papers in the air after playing with coronavirus regressions in matlab all afternoon.

Hell with this crap. I'm gonna go play video games. Let me know when we get to the part of the apocalypse where it's time to fight the sewer dwelling CHUDs.

So the part where we fight donnie then? Ok but by then there will be a line.
 

Kara Spengler

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But not surprising. He was going around shaking hands and totally ignoring any social distance protocol. Wtf did he think would happen?
That he would be as immune as donnie thinks he is? I wish world leaders would not think of themselves as different than anyone else of the same age and health profile.
 
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Kara Spengler

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I'm not really satisfied with the position taken by Dr. Patrice Harris on hydroxychloroquine in this interview. She's President of the American Medical Association and says she would not prescribe it to anyone. In this interview she emphasizes that it could kill a patient and takes a bureaucratic line of "It's not approved, so I won't use it."

Drugs are often prescribed by doctors for off-label uses. Just because it is not officially approved for some use does not mean it cannot be prescribed. That's where anecdotal evidence comes from that prompts studies that lead to becoming officially approved. Also, the drug is quite old and one could argue that its side effects are probably better understood than newer medications. It could be harmful, but doctors know the risks and should balance those risks with the risks of doing nothing or trying some other less familiar drug. It has been used in South Korea and China, and limited non-placebo trials have demonstrated benefits.

I suspect she is motivated in her statements more by the problems of hydroxycholoroquine hoarding and the needs of lupus and rheumatoid arthritis patients which is understandable, but she does not talk about that. It reminds me of face masks. In the Asian Boss interview of Dr. Kim from South Korea, he was mystified by countries at that time advising against wearing masks unless it was due to shortages. It strikes me that Harris has been caught up in the soap opera generated by Trump, and CNN in promoting this video (currently on cnn.com coronavirus playlist) is using that soap opera for their news.

Gov. Cuomo seemed to have a more reasonable response to the question in his briefing today. where he mentions that hospitals can use it at their discretion and that limits have been placed on prescriptions to prevent hoarding.
Personally I am hoping one of the other drugs in the trial does better than it. From one I understand I am one of the ppl who donnie does not think exist who can not just take it. It causes seizures.
 
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Sovereignty

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J.K. Rowling shared this video on breathing exercises. News is she has recovered from C19.


ETA: The bit about the pillow and lying face down is confusing to a lot of people in the comments. Needs some help there.
 
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Stora

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NZ health minister breaks lockdown at beach

New Zealand's health minister has called himself an "idiot" after breaking the country's lockdown by driving his family to the beach.

David Clark admitted the 12-mile (20km) drive was "a clear breach of the lockdown principles".

He offered his resignation to Prime Minister Jacinda Ardern, but kept his job because of the ongoing crisis.




'Idiot' NZ health minister breaks lockdown at beach
 

Innula Zenovka

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The BBC was allowed to film inside University College Hospital, London, where the post-op recovery area has been turned into an intensive care ward to treat Covid-19 patients

 

Innula Zenovka

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Trump made his first endorsement of hydroxychloroquine on 19 March. Export controls, shortages, overdoses, and scientific recriminations rapidly ensued, but the controversy could not extinguish the power of presidentially endorsed hope. Across the globe and throughout diverse communities on the internet, hydroxychloroquine had been anointed the miracle cure for Covid-19.

The only problem? The study that all this fervid hope is based on doesn’t show what its authors claim it does.

The gold standard for a clinical trial is a double-blinded, randomized controlled trial (RCT). What this means in plain English is that the study has been designed to reduce biases that would render its results meaningless. Neither the physician nor the patients knows whether they received the drug (“double-blinded”), a safeguard that reduces the possibility that the doctor will treat the two groups differently. The researchers also do not get to choose which patients go into which group (“randomized”) and the makeup of the two groups is roughly equivalent (“controlled”).

The French hydroxychloroquine study did not follow any of these rules.
Among the many issues with the trial is that the way it was set up excluded from the results patients in the test group who either went into intensive care, had to abandon the trial because of nausea, or died while taking the drug:

If you had only heard about this study from the Fox News assertion of a “100% cure rate”, you might assume that the four patients with poor clinical outcomes (the three ICU visits and one death) had been unlucky enough to be in the group that did not receive the “cure”.

And yet, those four patients, as well as the patient with nausea and the one who left the hospital early, were all part of the treatment group. They were excluded from the topline results of the study because of the way that the researchers chose to measure and report the results: strictly based on the measurable presence of viruses in nasal swabs taken each day of the study. Since the patients were in the ICU or dead, their samples could not be taken and they were left out of the final analysis. Based on the nasal swabs of just the 36 patients who completed the study, those who received the drug cleared the virus from their systems faster than those who did not.

This is how an experiment in which 15% of the treatment group and 0% of the control had poor clinical outcomes could end up being reported as showing a “100% cure rate”.
 

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But not surprising. He was going around shaking hands and totally ignoring any social distance protocol. Wtf did he think would happen?
Most dont catch it full on, but only have mild or no symptoms - of course he believed in the superiority of his own genes,...
 
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