- Mar 27, 2020
- SL Rez
Now I know why the people on TWIV have been making snide comments about ferrets!Substance has had promising results in ferrets, with hopes it may reduce transmissionwww.theguardian.com
(Also posted in Ferrets for Couldbe)
There may be a better virus-animal model now.
The last TWIV (microbe.tv and youtube) discussed the development of a strain of SARS-CoV2 in the lab that produces quite similar symptoms in a standard type of lab mice. The TWIVers were excited. No one could use mice before since the ACE2 receptor differs and SARS-CoV-2 did not cause disease in mice.
It was relatively easy to do. Spray human virus up their noses (mouse noses), wait a day or two, harvest the virus found in the lungs. Repeat nine more times. After ten iterations they had a virus with a limited number of mutations that has similar effects on these mice as found with COVID-19, e.g., increasing mortality/morbidity with age and lung damage. (The mutated virus no longer infects [or is it: causes disease in?] human cells. It is adapted to these mice.)
I thought the TWIVers were a little bit too excited, though Raccaniello did say, "Mice lie, and monkeys exaggerate."