In January 2005, Zoë Roth and her father Dave went to see a controlled burn - a fire intentionally started to clear a property - in their neighbourhood in Mebane, North Carolina.
Mr Roth, an amateur photographer, took a photo of his daughter smiling mischievously in front of the blaze.
After winning a photography prize in 2008, the image went viral when it was posted online.
Ms Roth has sold the original copy of her meme as a NFT for 180 Ethereum, a form of cryptocurrency, to a collector called @3FMusic.
The NFT is marked with a code that will allow the Roths - who have said they will split the profit - to keep the copyright and receive 10% of profits from future sales.